What is pregnenolone?
Pregnenolone is an endogenous steroid hormone. It is synthesized within the body from cholesterol via an enzyme located in mitochon- dria. Its production is controlled by hormones from the pituitary gland, like ACTH, FSH, & LH. Pregnenolone is biologically active on its own and also is a precursor of progesterone, mineralocorticoids (like aldosterone), glucocorticoids (like cortisol), androgens (like DHEA and testosterone), and estrogen.Because it is the precursor to all of these other hormones, it is sometimes known as ‘the mother hormone.’ This hormone acts as a “neurosteroid.” It is found in high concentrations in certain areas of the brain. Pregnenolone affects synaptic functions, is neuroprotective, and enhances myelinization. Cholesterol is the precursor to pregnenolone. Then pregnenolone can convert to either progesterone or to 17 alpha hydroxypregnenolone, and thereafter it can be shunted to cortisol or down a different pathway to DHEA then testosterone and estradiol (estrogen).
Pregnenolone “Steal”
Again, cholesterol is the basic molecule of the endocrine system. Cholesterol is converted to pregnenolone, and pregnenolone is building block for many of the other hormones. When a person is under a great deal of stress, the endocrine system is activated by the HPA axis- hypothalamic-pituitary-adrenal axis- to increase production of cortisol and adrenaline (epinephrine). The hypothalamus makes CRH (corticotropin-releasing hormone) to stimulate the pituitary gland to make ACTH (adrenocorticotropic hormone) which stimu- lates the adrenal glands to produce cortisol. Cortisol is then released into the blood stream. The body manufactures cortisol in response to prolonged stress. Cortisol’s actions in this setting include those to promote a fight-or-flight response: increased heart rate and respira- tion rate; dilated pupils; sweating; inhibited digestion; suppressed immune activities. The body uses whatever building blocks it can to synthesize large amounts of cortisol. This includes diverting pregnen- olone, a building block of steroid hormones, from its normal function to increased production of cortisol at the expense of other hormones.
Pregnenolone Uses
There are many potential uses of pregnenolone in clinical practice, some based on research in animals or humans, and some based on theoretical utility. Here are some examples of what practitioners are using pregnenolone for: PTSD, traumatic brain injury (shortly after the injury has occurred), allergies, insomnia (dosed in the morning), adrenal fatigue, focus, mental clarity, memory, social phobia, anxiety, depressed mood.
- Serving Size: 1 Fast Melt Chewable
- Servings Per Container: 120
- Pregnenolone: 25mg
Other Ingredients: waxy rice starch, microcrystalline cellulose, fructose, xylitol, stearic acid, natural strawberry flavor, silicone dioxide, vegetable stearate.
Suggested Use: As a dietary supplement, take 1 fast melt chewable daily, or as directed by your healthcare practitioner.
WARNING: Not for use by individuals under the age of 18 years. Do not take this product if you are pregnant, nursing, or planning to become pregnant, on hormone therapy, have a hormone related cancer or condition, are taking DHEA supplements or if you have a heart condition. Do not exceed recommended servings. Exceeding recommended servings may cause serious adverse head effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, insomnia, anxiety, and irregular heart rhythm.
Caution: Discontinue use and call a physician immediately if you experience rapid heartbeat, dizziness, blurred vision or other similar symptoms. This product may interfere with birth control medications or devices.
Keep out of reach of children. Store in a cooler, dry place.
