There is growing evidence that neuroinflammation may be the underpinning of addictive behavior. Chronic drug use leaves the brain more vulnerable to inflammation and neuropathology. This chronic neuroinflammation leads to brain dysfunction, promotes drug-using behavior and impairs cognitive control. It is believed that repeated use of addictive substances, despite the known harm, may be an unconscious effort by the addicted person to dampen neuroinflammation. Studies show that nonpharmacological methods of controlling inflammation may reduce drug-induced neurotoxicity and may be a substantial part of a successful recovery from addiction.